HOUSTON, TX – December 1, 2011 – Texas Heart Institute and MicroMed Cardiovascular, Inc.
announced today, during the opening of the 6th Annual European Mechanical Circulatory
Support Summit in Paris, a new record has been established for an animal supported by an
Electronic, Continuous Flow, Total Artificial Heart. A calf was successfully supported for 91 days
by two modified HeartAssist 5® Continuous Flow LVADs, manufactured by MicroMed
Cardiovascular, Inc. of Houston, TX, USA, under a special NIH Research Grant to advance
Total Artificial Heart Technology. This achievement broke the previous record for continuous
flow total artificial heart animal support of 60 days, also at Texas Heart Institute, and using
two modified HeartAssist 5® LVADS earlier this year.

Dr. Bud Frazier, together with Dr. Billy Cohn of the Center for Cardiac Support at Texas
Heart Institute, commented, “The Study Protocol defines success at 60 days but this calf
did so well we modified the protocol to extend the protocol to 90 days and are very pleased
with the results.” David Mackstaller, CEO for MicroMed Cardiovascular, Inc., commented,
“We have worked with Texas Heart Institute for many years and we are excited to have
contributed to this important milestone. We remain firmly committed to advancements in
mechanical support to ultimately make a difference in restoring the lives of patients suffering
from heart failure around the world.”

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